Cell based therapies in lower urinary tract disordersCell based therapies in lower urinary tract disorders
Faculty of Medicine and Health Sciences
Vaccine & Infectious Disease Institute (VAXINFECTIO)
Translational Neurosciences (TNW)
Cell transplantation. - Amsterdam
24(2015):9, p. 1679-1686
University of Antwerp
Cell based therapy for the bladder has its beginnings in the 90s with the successful isolation and culture of bladder smooth muscle cells. Since then several attempts have been made to artificially implant native cell-types and stem cell-derived cells into damaged bladders in the form of single-cell injectables or as grafts seeded onto artificial extra cellular matrix. We critically examined in literature, the types of cells and their probable role as an alternative to non-drug based, non-bowel based graft replacement therapy in disorders of the urinary bladder. The limitations and plausible improvements to these novel therapies have also been discussed keeping in mind an ideal therapy that could suit most bladder abnormalities arising out of varied number of disorders. In conclusion, muscle-derived cell types have consistently proven to be a promising therapy to emerge in the coming decade. However, tissue-engineered constructs have yet to prove their success in pre-clinical and long-term clinical setting.