Title
Cell based therapies in lower urinary tract disorders Cell based therapies in lower urinary tract disorders
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Biology
Human medicine
Source (journal)
Cell transplantation. - Amsterdam
Volume/pages
24(2015) :9 , p. 1679-1686
ISSN
0963-6897
ISI
000361419700002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Cell based therapy for the bladder has its beginnings in the 90s with the successful isolation and culture of bladder smooth muscle cells. Since then several attempts have been made to artificially implant native cell-types and stem cell-derived cells into damaged bladders in the form of single-cell injectables or as grafts seeded onto artificial extra cellular matrix. We critically examined in literature, the types of cells and their probable role as an alternative to non-drug based, non-bowel based graft replacement therapy in disorders of the urinary bladder. The limitations and plausible improvements to these novel therapies have also been discussed keeping in mind an ideal therapy that could suit most bladder abnormalities arising out of varied number of disorders. In conclusion, muscle-derived cell types have consistently proven to be a promising therapy to emerge in the coming decade. However, tissue-engineered constructs have yet to prove their success in pre-clinical and long-term clinical setting.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/cce6a1/4d81c916.pdf
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