Title
Mouse models to unravel the role of inhaled pollutants on allergic sensitization and airway inflammation Mouse models to unravel the role of inhaled pollutants on allergic sensitization and airway inflammation
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
London ,
Subject
Human medicine
Source (journal)
Respiratory research. - London
Volume/pages
11(2010) , p. 1-16
ISSN
1465-9921
Article Reference
7
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Air pollutant exposure has been linked to a rise in wheezing illnesses. Clinical data highlight that exposure to mainstream tobacco smoke (MS) and environmental tobacco smoke (ETS) as well as exposure to diesel exhaust particles (DEP) could promote allergic sensitization or aggravate symptoms of asthma, suggesting a role for these inhaled pollutants in the pathogenesis of asthma. Mouse models are a valuable tool to study the potential effects of these pollutants in the pathogenesis of asthma, with the opportunity to investigate their impact during processes leading to sensitization, acute inflammation and chronic disease. Mice allow us to perform mechanistic studies and to evaluate the importance of specific cell types in asthma pathogenesis. In this review, the major clinical effects of tobacco smoke and diesel exhaust exposure regarding to asthma development and progression are described. Clinical data are compared with findings from murine models of asthma and inhalable pollutant exposure. Moreover, the potential mechanisms by which both pollutants could aggravate asthma are discussed.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/6d8680/b2486608.pdf
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