Title
Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Springfield, Ill. ,
Subject
Human medicine
Source (journal)
Journals of gerontology : series A : biological sciences and medical sciences. - Springfield, Ill.
Volume/pages
69(2014) :5 , p. 532-544
ISSN
1079-5006
ISI
000334738000006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Calorie restriction (CR) is a lifestyle intervention employed to reduce body weight and improve metabolic functions primarily via reduction of ingested carbohydrates and fats. Taste perception is highly related to functional metabolic status and body adiposity. We have previously shown that sweet taste perception diminishes with age; however, relatively little is known about the effects of various lengths of CR upon taste cell morphology and function. We investigated the effects of CR on taste bud morphology and expression of sweet tasterelated modulators in 5-, 17-, and 30-month-old rats. In ad libitum (AL) and CR rats, we consistently found the following parameters altered significantly with advancing age: reduction of taste bud size and taste cell numbers per taste bud and reduced expression of sonic hedgehog, type 1 taste receptor 3 (T1r3), -gustducin, and glucagon-like peptide-1 (GLP-1). In the oldest rats, CR affected a significant reduction of tongue T1r3, GLP-1, and -gustducin expression compared with age-matched AL rats. Leptin receptor immunopositive cells were elevated in 17- and 30-month-old CR rats compared with age-matched AL rats. These alterations of sweet tasterelated modulators, specifically during advanced aging, suggest that sweet taste perception may be altered in response to different lengths of CR.
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