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Title
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Systems analysis of arrestin pathway functions
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Author
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Abstract
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| To fully appreciate the diversity and specificity of complex cellular signaling events, such as arrestin-mediated signaling from G protein-coupled receptor activation, a complex systems-level investigation currently appears to be the best option. A rational combination of transcriptomics, proteomics, and interactomics, all coherently integrated with applied next-generation bioinformatics, is vital for the future understanding of the development, translation, and expression of GPCR-mediated arrestin signaling events in physiological contexts. Through a more nuanced, systems-level appreciation of arrestin-mediated signaling, the creation of arrestin-specific molecular response "signatures" should be made simple and ultimately amenable to drug discovery processes. Arrestin-based signaling paradigms possess important aspects, such as its specific temporal kinetics and ability to strongly affect transcriptional activity, that make it an ideal test bed for next-generation of drug discovery bioinformatic approaches such as multi-parallel dose response analysis, data texturization, and latent semantic indexing-based natural language data processing and feature extraction. |
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Language
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English
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Source (journal)
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Progress in molecular biology and translational science. - London
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Publication
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London
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2013
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ISSN
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1877-1173
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DOI
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10.1016/B978-0-12-394440-5.00017-6
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Volume/pages
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118
(2013)
, p. 431-467
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ISI
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000321874600018
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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