Title
Age-related changes in mouse taste bud morphology, hormone expression, and taste responsivity Age-related changes in mouse taste bud morphology, hormone expression, and taste responsivity
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Springfield, Ill. ,
Subject
Human medicine
Source (journal)
Journals of gerontology : series A : biological sciences and medical sciences. - Springfield, Ill.
Volume/pages
67(2012) :4 , p. 336-344
ISSN
1079-5006
ISI
000301974500003
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Normal aging is a complex process that affects every organ system in the body, including the taste system. Thus, we investigated the effects of the normal aging process on taste bud morphology, function, and taste responsivity in male mice at 2, 10, and 18 months of age. The 18-month-old animals demonstrated a significant reduction in taste bud size and number of taste cells per bud compared with the 2- and 10-month-old animals. The 18-month-old animals exhibited a significant reduction of protein gene product 9.5 and sonic hedgehog immunoreactivity (taste cell markers). The number of taste cells expressing the sweet taste receptor subunit, T1R3, and the sweet taste modulating hormone, glucagon-like peptide-1, were reduced in the 18-month-old mice. Concordant with taste cell alterations, the 18-month-old animals demonstrated reduced sweet taste responsivity compared with the younger animals and the other major taste modalities (salty, sour, and bitter) remained intact.
E-info
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