Title
Live longer sans the <tex>$AT_{1A}$</tex> receptor Live longer sans the <tex>$AT_{1A}$</tex> receptor
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
,
Subject
Biology
Human medicine
Source (journal)
Cell metabolism. - Place of publication unknown
Volume/pages
9(2009) :5 , p. 403-405
ISSN
1550-4131
ISI
000265841700003
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Excessive activation of the AT(1A) receptor (AT(1A)R) by angiotensin II (Ang II) is implicated in the age-related development of hypertension, diabetes, and kidney disease. AT(1A)R-deficient mice live longer and have lower levels of oxidative stress than wild-type mice (Benigni et al., 2009), suggesting a role for AT(1A)R signaling in the aging process.
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