Title
Modulation of taste sensitivity by GLP-1 signaling in taste buds Modulation of taste sensitivity by GLP-1 signaling in taste buds
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
New York, N.Y. ,
Subject
Psychology
Biology
Human medicine
Engineering sciences. Technology
Source (journal)
Annals of the New York Academy of Sciences / New York Academy of Sciences. - New York, N.Y.
Volume/pages
1170(2009) , p. 98-101
ISSN
0077-8923
ISI
000270495700022
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Modulation of sensory function can help animals adjust to a changing external and internal environment. Even so, mechanisms for modulating taste sensitivity are poorly understood. Using immunohistochemical, biochemical, and behavioral approaches, we found that the peptide hormone glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R) are expressed in mammalian taste buds. Furthermore, we found that GLP-1 signaling plays an important role in the modulation of taste sensitivity: GLP-1R knockout mice exhibit a dramatic reduction in sweet taste sensitivity as well as an enhanced sensitivity to umami-tasting stimuli. Together, these findings suggest a novel paracrine mechanism for the hormonal modulation of taste function in mammals.
E-info
https://repository.uantwerpen.be/docman/iruaauth/af85ad/f568958.pdf
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