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Title
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Modulation of taste sensitivity by GLP-1 signaling in taste buds
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Author
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Abstract
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| Modulation of sensory function can help animals adjust to a changing external and internal environment. Even so, mechanisms for modulating taste sensitivity are poorly understood. Using immunohistochemical, biochemical, and behavioral approaches, we found that the peptide hormone glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R) are expressed in mammalian taste buds. Furthermore, we found that GLP-1 signaling plays an important role in the modulation of taste sensitivity: GLP-1R knockout mice exhibit a dramatic reduction in sweet taste sensitivity as well as an enhanced sensitivity to umami-tasting stimuli. Together, these findings suggest a novel paracrine mechanism for the hormonal modulation of taste function in mammals. |
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Language
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English
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Source (journal)
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Annals of the New York Academy of Sciences. - New York, N.Y., 1877, currens
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Publication
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New York, N.Y.
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2009
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ISSN
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0077-8923
[print]
1749-6632
[online]
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DOI
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10.1111/J.1749-6632.2009.03920.X
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Volume/pages
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1170
(2009)
, p. 98-101
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ISI
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000270495700022
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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