Publication
Title
A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin
Author
Abstract
The ageing process and its associated diseases all involve perturbed energy metabolism, oxidative damage. and an impaired ability of the organism and its cells to cope with adversity. We propose that some specific signaling pathways in the brain may be important determinants of health during ageing. Among such specific signaling modalities are those activated in neurons by insulin-like growth factors (IGFs), brain-derived neurotrophic factor (BDNF) and serotonin. This triumvirate may be particularly important because of their cooperative influence on energy metabolism, food intake, stress responses and cardiovascular function. The health benefits to the periphery and central nervous system of dietary restriction and exercise may be mediated by this triumvirate of signals in the brain. At the molecular level, BDNF, serotonin and IGFs can all stimulate the production of proteins involved in cellular stress adaptation, growth and repair, neurogenesis, learning and memory and cell survival. The importance of this triumvirate is emphasized when it is seen that their general roles in energy metabolism, stress adaptation and disease resistance are conserved among diverse organisms consistent with important roles in the ageing process. Published by Elsevier Ireland Ltd.
Language
English
Source (journal)
Ageing research reviews. - Baltimore, Md
Publication
Baltimore, Md : 2004
ISSN
1568-1637
Volume/pages
3:4(2004), p. 445-464
ISI
000226508400006
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 06.01.2015
Last edited 19.06.2017