Title
BDNF and 5-HT : a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders BDNF and 5-HT : a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Cambridge ,
Subject
Human medicine
Source (journal)
Trends in neurosciences. - Cambridge
Volume/pages
27(2004) :10 , p. 589-594
ISSN
0166-2236
ISI
000224509000005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are known to regulate synaptic plasticity, neurogenesis and neuronal survival in the adult brain. These two signals co-regulate one another such that 5-HT stimulates the expression of BDNF, and BDNF enhances the growth and survival of 5-HT neurons. Impaired 5-HT and BDNF signaling is central to depression and anxiety disorders, but could also play important roles in the pathogenesis of several age-related disorders, including insulin resistance syndrome, Alzheimer's disease and Huntington's disease. Enhancement of BDNF signaling may be a key mechanism whereby cognitive stimulation, exercise, dietary restriction and antidepressant drugs preserve brain function during aging. Behavioral and pharmacological manipulations that enhance 5-HT and BDNF signaling could help promote healthy brain aging.
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