Title
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BDNF and 5-HT : a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders
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Author
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Abstract
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Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are known to regulate synaptic plasticity, neurogenesis and neuronal survival in the adult brain. These two signals co-regulate one another such that 5-HT stimulates the expression of BDNF, and BDNF enhances the growth and survival of 5-HT neurons. Impaired 5-HT and BDNF signaling is central to depression and anxiety disorders, but could also play important roles in the pathogenesis of several age-related disorders, including insulin resistance syndrome, Alzheimer's disease and Huntington's disease. Enhancement of BDNF signaling may be a key mechanism whereby cognitive stimulation, exercise, dietary restriction and antidepressant drugs preserve brain function during aging. Behavioral and pharmacological manipulations that enhance 5-HT and BDNF signaling could help promote healthy brain aging. |
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Language
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English
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Source (journal)
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Trends in neurosciences. - Cambridge
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Publication
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Cambridge
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2004
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ISSN
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0166-2236
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DOI
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10.1016/J.TINS.2004.08.001
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Volume/pages
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27
:10
(2004)
, p. 589-594
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ISI
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000224509000005
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Full text (Publisher's DOI)
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