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Title
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Large decrease of anti-tetanus anatoxin and anti-pneumococcal antibodies at one year after renal transplantation
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Author
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Abstract
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| Aims: In kidney transplant recipients (KTR), antibody (Ab) synthesis is hampered by AZA and CsA. We here report in a prospective cohort study, the effects of mycophenolate mofetil (MMF) associated to a calcineurin inhibitor on plasma levels of anti-tetanus anatoxin Ab (TAnAb) and anti-pneumococcal Ab (PnPsAb). Methods: Serum titers of the TAnAb and the PnPsAb against serotypes 14, 19F and 23F were measured in 94 KTR on Day 0 (TO) and 1 year (T12) after renal transplantation and in 49 healthy controls. Results: 1) At TO, TAnAb were detected in only 71% of patients vs. 98% of controls (p < 0.0001) and the titers were significantly lower in KTR (1.46 UI/ml vs. 2.74 in controls, p = 0.01); they further decreased between TO and T12 (1.46 UI/ml to 0.31, p < 0.0001). The calculated half-life (t(1/2)) of TAnAb was 7.7 months, as compared to more than 10 years in a normal population. 2) In KTR, PnPsAb titers decreased significantly between TO and T12 (p < 0.005); the t(1/2) of the different PnPsAb ranged from 9.2 to 11.9 months. Conclusions: In KTR treated by MMF and CNI, the TAnAbs and PnPsAbs titers decrease significantly and profoundly during the first year. Immunization pre-transplantation should be encouraged to maintain adequate post-transplant Abs levels. |
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Language
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English
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Source (journal)
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Clinical nephrology. - München
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Publication
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München
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2013
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ISSN
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0301-0430
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DOI
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10.5414/CN107779
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Volume/pages
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79
:4
(2013)
, p. 313-317
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ISI
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000320840200008
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Full text (Publisher's DOI)
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Full text (open access)
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