Title
The once-daily formulation of tacrolimus : a step forward in kidney transplantation? The once-daily formulation of tacrolimus : a step forward in kidney transplantation?
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Baltimore, Md ,
Subject
Human medicine
Source (journal)
Transplantation. - Baltimore, Md, 1963, currens
Volume/pages
93(2012) :3 , p. 241-243
ISSN
0041-1337
ISI
000300193200006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Nonadherence is a critical issue in transplantation. Recently, Astellas designed a once-daily-extended release formulation of tacrolimus (Tac). Despite initial reports showing bioequivalence of Tac once-daily (Advagraf) with the original formulation requiring twice-daily intake (Tac twice-daily, Prograf), several groups have now shown a sustained decrease in Tac exposure upon conversion from Prograf to Advagraf. Here, we discuss the possible reasons for this observation and how it could affect the expected benefits of Advagraf, and we comment on the fact that a similar lack of bioequivalence might prevail with generic immunosuppressive drugs.
E-info
https://repository.uantwerpen.be/docman/iruaauth/a7fa18/1299010.pdf
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