Title
Influenza A/H1N1 vaccine in patients treated by kidney transplant or dialysis : a cohort study Influenza A/H1N1 vaccine in patients treated by kidney transplant or dialysis : a cohort study
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Baltimore, Md ,
Subject
Human medicine
Source (journal)
Clinical journal of the American Society of Nephrology. - Baltimore, Md
Volume/pages
6(2011) :11 , p. 2573-2578
ISSN
1555-9041
ISI
000296821300006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Background and objectives In 2009, the pandemic influenza A/H1N1 accounted for worldwide recommendations about vaccination. There are few data concerning the immunogenicity or the security of the adjuvanted-A/H1N1 vaccine in transplanted and hemodialyzed patients. Design, setting, participants, & measurements Sera from 21 controls, 53 hemodialyzed (HD) patients, and 111 renal transplant recipients (RT) were sampled before (T0) and 1 month after (T1) a single dose of Pandemrix (R) vaccine (GSK Biologicals, AS03-adjuvanted). We measured the neutralizing antibodies against A/H1N1/2009, the geometric mean (GM) titers, the GM titer ratios (T1/T0) with 95% confidence intervals, and the seroconversion rate (responders: >= 4-fold increase in titer). The HLA and MICA immunization was determined by Luminex technology. Results The GM titer ratio was 38 (19 to 78), 9 (5 to 16), and 5 (3 to 6) for controls, HD patients, and RI patients, respectively (P < 0.001). The proportion of responders was 90%, 57%, and 44%, respectively (P < 0.001). In RT patients, the prevalence of histocompatibility leukocyte antigen (HLA) class I, histocompatibility leukocyte antigen class 11, and MHC class I-related chain A immunization, was, respectively, 15%, 14%, and 14% before and 14%, 14%, and 11% after vaccination (P = 1, 1, and 0.39). Conclusions The influenza A/H1N1-adjuvanted vaccine is of limited efficacy but is safe in renal disease populations. The humoral response is lower in transplanted versus hemodialyzed patients. Further studies are needed to improve the efficacy of vaccination in those populations. Clin J Am Soc Nephrol 6: 2573-2578, 2011. doi: 10.2215/CJN.04670511
Full text (open access)
https://repository.uantwerpen.be/docman/irua/b09314/9013.pdf
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