Title
FTY720 combined with tacrolimus in de novo renal transplantation : 1-year, multicenter, open-label randomized study FTY720 combined with tacrolimus in de novo renal transplantation : 1-year, multicenter, open-label randomized study
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Berlin ,
Subject
Human medicine
Source (journal)
Nephrology, dialysis, transplantation. - Berlin
Volume/pages
26(2011) :11 , p. 3802-3805
ISSN
0931-0509
ISI
000296350400060
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Background. FTY720 (fingolimod), a novel immunomodulator, has demonstrated potential for prevention of acute rejection in combination with cyclosporine. Methods. This study evaluated FTY720 2.5 mg versus mycophenolate mofetil (MMF) in a combination regimen with standard tacrolimus and corticosteroids in de novo renal transplant recipients for the composite efficacy within 6 months of transplantation. Results. Incidence of treated biopsy-proven acute rejection was 22.9% with FTY720 and 18.5% with MMF. Increased incidence of macular oedema, transient decrease in heart rate and low rate of infections were seen in the FTY720 arm. Conclusion. FTY720 combined with tacrolimus and steroids did not show a significant therapeutic advantage over MMF for the prevention of acute rejection in de novo renal transplant recipients.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/b769fe/9015.pdf
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