Title
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Thrombophilic factors in Stage V chronic kidney disease patients are largely corrected by renal transplantation
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Author
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Abstract
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Background. The aim of our study was to evaluate the prevalence of acquired thrombophilic factors in Stage V chronic kidney disease (CKD) patients according to dialysis modality, the rate of correction of these factors 1 month after renal transplantation and their impact on cardiovascular or thromboembolic events at 1 year. Methods. Three hundred and ten patients were prospectively screened for seven thrombophilic factors at transplantation; 215 of them were also assayed 1 month after. All the patients received prophylactic acetylsalicylic acid, started before transplantation. Results. The prevalence of thrombophilic factors was significantly higher in patients under dialysis (n = 289) than in patients not yet on dialysis (n = 21) (74 versus 52.4%; P = 0.03) but was similar in haemodialysis and peritoneal dialysis patients (74.2 versus 73.2%). One month after transplantation, the global prevalence of thrombophilic factors had dropped from 74.4 to 44.7% (P <0.001). Most thrombophilic factors had disappeared after transplantation: antithrombin deficiency: 13.5 versus 0.9%; P <0.001, protein C deficiency: 12.1 versus 1.9%; P <0.001, protein S deficiency: 3.7 versus 1.4%; P = 0.1, lupus anticoagulant: 37.7 versus 8.4%; P <0.001 and anti-phospholipid antibodies: 29.3 versus 12.6%; P <0.001. The prevalence of activated protein C resistance, which reflects inherited factor V (FV) Leiden, was unchanged (1.9%), while the prevalence of elevated factor VIIIc increased from 20.9 to 30.7%, P <0.001. The incidence of cardiovascular or thromboembolic events 1 year after transplantation was similar in patients with more than or equal to one thrombophilic factor at 1 month (5.2%) versus thrombophilic-free patients (6.7%). Conclusion. Acquired thrombophilic factors are highly prevalent among Stage V CKD patients. Most thrombophilic factors are corrected 1 month after transplantation. |
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Language
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English
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Source (journal)
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Nephrology, dialysis, transplantation. - Berlin
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Publication
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Berlin
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2011
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ISSN
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0931-0509
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DOI
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10.1093/NDT/GFQ791
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Volume/pages
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26
:8
(2011)
, p. 2700-2705
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ISI
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000293336500045
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Full text (Publisher's DOI)
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Full text (open access)
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