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Title
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Bortezomib : a new player in pre- and post-transplant desensitization?
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Author
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Abstract
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| Several desensitization strategies have been investigated for the reversal of acute antibody-mediated rejection or for the removal of preformed anti-HLA antibodies, with the aim to promote access to renal transplantation. Today, their success appears limited or incomplete. Bortezomib, a selective inhibitor of the 26S proteasome, which is largely used in the treatment of multiple myeloma, could be a novel promising desensitizing agent. Its mechanism of action and preliminary clinical use in renal transplantation is reviewed here. |
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Language
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English
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Source (journal)
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Nephrology, dialysis, transplantation. - Berlin
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Publication
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Oxford
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Oxford univ press
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2010
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ISSN
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0931-0509
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DOI
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10.1093/NDT/GFQ502
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Volume/pages
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25
:11
(2010)
, p. 3480-3489
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ISI
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000283683900006
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Full text (Publisher's DOI)
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Full text (open access)
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