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Title
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Thrombophilic factors do not predict outcomes in renal transplant recipients under prophylactic acetylsalicylic acid
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Author
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Abstract
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| The rate of thromboembolic events or acute rejection episodes during the first posttransplant year (primary composite endpoint) was 16.7% among patients free of thrombophilic factor (N = 60) and 17.2% in those with >= 1 thrombophilic factor (N = 250) (p > 0.99). The incidence of the primary endpoint was similar among patients free of thrombophilic factors and those with >= 2 (N = 135), or >= 3 (N = 53) factors (16.3% and 15.1% respectively; p = 1) and in patients who remained thrombophilic at 1 month (15.7%; p = 0.84). None of the individual thrombophilic factor present at the day of transplantation was associated with the primary endpoint. The incidence of cardiovascular events at 1-year, serum creatinine at 1-year, 4-year actuarial graft and patient survival were not influenced by the presence of >= 1 thrombophilic factor at baseline (p = NS). In conclusion, the presence of thrombophilic factors does not influence thromboembolic events, acute rejection, graft or patient survival in patients transplanted after 2000 and receiving prophylactic acetylsalicylic acid. |
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Language
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English
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Source (journal)
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American journal of transplantation. - Copenhagen
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Publication
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Copenhagen
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2010
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ISSN
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1600-6135
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DOI
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10.1111/J.1600-6143.2009.02855.X
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Volume/pages
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10
:1
(2010)
, p. 99-105
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ISI
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000272882000016
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Full text (Publisher's DOI)
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Full text (open access)
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