Title
Thrombophilic factors do not predict outcomes in renal transplant recipients under prophylactic acetylsalicylic acid Thrombophilic factors do not predict outcomes in renal transplant recipients under prophylactic acetylsalicylic acid
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Copenhagen ,
Subject
Human medicine
Source (journal)
American journal of transplantation. - Copenhagen
Volume/pages
10(2010) :1 , p. 99-105
ISSN
1600-6135
ISI
000272882000016
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
The rate of thromboembolic events or acute rejection episodes during the first posttransplant year (primary composite endpoint) was 16.7% among patients free of thrombophilic factor (N = 60) and 17.2% in those with >= 1 thrombophilic factor (N = 250) (p > 0.99). The incidence of the primary endpoint was similar among patients free of thrombophilic factors and those with >= 2 (N = 135), or >= 3 (N = 53) factors (16.3% and 15.1% respectively; p = 1) and in patients who remained thrombophilic at 1 month (15.7%; p = 0.84). None of the individual thrombophilic factor present at the day of transplantation was associated with the primary endpoint. The incidence of cardiovascular events at 1-year, serum creatinine at 1-year, 4-year actuarial graft and patient survival were not influenced by the presence of >= 1 thrombophilic factor at baseline (p = NS). In conclusion, the presence of thrombophilic factors does not influence thromboembolic events, acute rejection, graft or patient survival in patients transplanted after 2000 and receiving prophylactic acetylsalicylic acid.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/009ac0/9024.pdf
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