Title
TCF7L2 polymorphism associates with new-onset diabetes after transplantationTCF7L2 polymorphism associates with new-onset diabetes after transplantation
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Baltimore, Md,
Subject
Human medicine
Source (journal)
Journal of the American Society of Nephrology. - Baltimore, Md, 1990, currens
Volume/pages
20(2009):11, p. 2459-2467
ISSN
1046-6673
ISI
000272261600023
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
New-onset diabetes after transplantation (NODAT) is a serious and frequent complication in transplant recipients. Whether NODAT shares the same susceptibility genes as type 2 diabetes is unknown. In this multicenter study, we genotyped 1076 white patients without diabetes at transplantation for 11 polymorphisms that associate with type 2 diabetes. We defined NODAT as a fasting plasma glucose >= 126 mg/dl on at least two occasions or de novo hypoglycemic therapy. We compared clinical and genetic factors between patients who developed NODAT within 6 mo of transplantation (n = 118; incidence 11 %) and patients without diabetes (n = 958). In multivariate analysis, NODAT significantly associated with the following characteristics: TCF7L2 polymorphism (odds ratio [OR] 1.60 per each T allele; P = 0.002), age (OR 1.03 per year; P < 0.001), body mass index at transplantation (OR 1.09 per unit; P < 0.001), tacrolimus use (OR 2.26; P < 0.001), and the occurrence of a corticoid-treated acute rejection episode (OR 2.78; P < 0.001). In summary, our data show that the TCF7L2 rs7903146 polymorphism, a known risk factor for type 2 diabetes in the general population, also associates with NODAT.
E-info
https://repository.uantwerpen.be/docman/iruaauth/29ad00/b4e9026.pdf
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