Title
First acute rejection episode after renal transplantation : study of the histopathological characteristics according to the immunological risk First acute rejection episode after renal transplantation : study of the histopathological characteristics according to the immunological risk
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
,
Subject
Human medicine
Source (journal)
Néphrologie & thérapeutique. - Place of publication unknown
Volume/pages
4(2008) :3 , p. 173-180
ISSN
1769-7255
ISI
000257281800005
Carrier
E
Target language
French (fre)
Full text (Publishers DOI)
Abstract
Renal allograft biopsies (n = 34) of two different populations of patients according to the immunological risk (high versus low-risk) have been compared retrospectively. The presence of polymorphonuclear leukocytes in peritubular capillaries was more frequent in the high-risk group. The C4d staining was positive in 10% of the low-risk patients and in 50% of the high-risk patients (P = 0.03). There were more early graft toss, renal infarctions, interstitial hemorrhage, severe glomerulitis, neutrophilic glomerulitis and Banff III grade rejection in the positive C4d group. In conclusion, half of the immunized patients had a humorat rejection, patients with a C4d positive rejection had more early graft loss and more severe histological lesions. (C) 2008 Elsevier Masson SAS et Association Societe de Nephrologie. Tous droits reserves.
E-info
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