Title
Hand transplantation : the state-of-the-artHand transplantation : the state-of-the-art
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Edinburgh :Churchill livingstone,
Subject
Human medicine
Source (journal)
JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME
Volume/pages
32E(2007):1, p. 2-17
ISSN
0266-7681
ISI
000244731100001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
The feasibility of hand transplantation has been demonstrated, both surgically and immunologically. Levels of immunosuppression comparable to regimens used in solid organ transplantation are proving sufficient to prevent graft loss. Many patients have achieved discriminative sensibility and recovery of intrinsic muscle function. In addition to restoration of function, hand transplantation offers considerable psychological benefits. The recipient's pre-operative psychological status, his motivation and his compliance with the intense rehabilitation programme are key issues. While the induction of graft specific tolerance represents a hope for the future, immunosuppression currently remains necessary and carries significant risks. Hand transplantation should, therefore, only be considered a therapeutic option for a carefully selected group of patients.
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