Title
Amplification of T-cell responses by neutrophils : relevance to allograft immunityAmplification of T-cell responses by neutrophils : relevance to allograft immunity
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Amsterdam :Elsevier science bv,
Subject
Human medicine
Source (journal)
Immunology letters. - Amsterdam
Source (book)
Annual Meeting of the French-Society-of-Immunology*, NOV 06, 2003, Juan les Pins, FRANCE
Volume/pages
94(2004):3, p. 163-166
ISSN
0165-2478
ISI
000223416500001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Because rejection of allografts is primarily caused by T and B lymphocyte responses to allogenic histocompatibility molecules, the role of innate immunity in organ transplant rejection is often overlooked. However, the very first damages to vascularized organ allografts are caused by ischemia-reperfusion, an inflammatory reaction involving activation of vascular endothelial cells and release of neutrophil chemoattractants. Herein, we review experimental observations suggesting that the early neutrophil influx in organ transplants favors T cell-mediated rejection. (C) 2004 Elsevier B.V. All rights reserved.
E-info
https://repository.uantwerpen.be/docman/iruaauth/0ab3d7/1339044.pdf
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