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Title
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Amplification of T-cell responses by neutrophils : relevance to allograft immunity
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Author
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Abstract
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| Because rejection of allografts is primarily caused by T and B lymphocyte responses to allogenic histocompatibility molecules, the role of innate immunity in organ transplant rejection is often overlooked. However, the very first damages to vascularized organ allografts are caused by ischemia-reperfusion, an inflammatory reaction involving activation of vascular endothelial cells and release of neutrophil chemoattractants. Herein, we review experimental observations suggesting that the early neutrophil influx in organ transplants favors T cell-mediated rejection. (C) 2004 Elsevier B.V. All rights reserved. |
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Language
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English
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Source (journal)
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Immunology letters. - Amsterdam
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Source (book)
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Annual Meeting of the French-Society-of-Immunology*, NOV 06, 2003, Juan les Pins, FRANCE
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Publication
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Amsterdam
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Elsevier science bv
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2004
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ISSN
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0165-2478
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DOI
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10.1016/J.IMLET.2004.04.017
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Volume/pages
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94
:3
(2004)
, p. 163-166
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ISI
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000223416500001
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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