Hypereosinophilic syndrome induced by neonatal immunization against MHC class II alloantigen : critical role of IL-4

Le Moine, A.; Flamand, V.; de Lavareille, A.; Abramowicz, D.; et al.

doi:10.1002/1521-4141(200201)32:1<174::AID-IMMU174>3.0.CO;2-L

Title

Hypereosinophilic syndrome induced by neonatal immunization against MHC class II alloantigen : critical role of IL-4

Author

Le Moine, A.

Flamand, V.

de Lavareille, A.

Abramowicz, D.

et al.

Abstract

A significant proportion of patients with the hypereosinophilic syndrome suffer from oligoclonal expansion of type 2 helper T lymphocytes (Th2). Herein, we first provide evidence that mice immunized at birth against a single MHC class II alloantigen develop pathological features mimicking this variant of the hypereosinophilic syndrome. Indeed, C57BL/6 mice injected at birth with (C57BL/6 x bm12)Fl spleen cells displayed T lymphocytes producing high levels of IL-5 and IL-13, increased blood eosinophil counts, eosinophilic infiltrates in various tissues, hyperplasia of lymphoid tissues, as well as serum hyperIgE. Moreover, eotaxin mRNA accumulated in the spleen of these animals. IL-4-deficient mice developed neither expansion of Th2 cells nor pathological changes except splenomegaly. Eotaxin mRNA accumulation was also prevented in these animals, We conclude that neonatal exposure to a single MHC class 11 alloantigen is sufficient to elicit an IL-4-dependent hypereosinophilic syndrome mimicking the lymphocytic variant of this disorder in humans.

Language

English

Source (journal)

European journal of immunology. - Weinheim

Publication

Weinheim : 2002

ISSN

0014-2980

DOI

10.1002/1521-4141(200201)32:1<174::AID-IMMU174>3.0.CO;2-L

Volume/pages

32 :1 (2002) , p. 174-181