Title
Hypereosinophilic syndrome induced by neonatal immunization against MHC class II alloantigen : critical role of IL-4 Hypereosinophilic syndrome induced by neonatal immunization against MHC class II alloantigen : critical role of IL-4
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Weinheim ,
Subject
Human medicine
Source (journal)
European journal of immunology. - Weinheim
Volume/pages
32(2002) :1 , p. 174-181
ISSN
0014-2980
ISI
000173527400020
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
A significant proportion of patients with the hypereosinophilic syndrome suffer from oligoclonal expansion of type 2 helper T lymphocytes (Th2). Herein, we first provide evidence that mice immunized at birth against a single MHC class II alloantigen develop pathological features mimicking this variant of the hypereosinophilic syndrome. Indeed, C57BL/6 mice injected at birth with (C57BL/6 x bm12)Fl spleen cells displayed T lymphocytes producing high levels of IL-5 and IL-13, increased blood eosinophil counts, eosinophilic infiltrates in various tissues, hyperplasia of lymphoid tissues, as well as serum hyperIgE. Moreover, eotaxin mRNA accumulated in the spleen of these animals. IL-4-deficient mice developed neither expansion of Th2 cells nor pathological changes except splenomegaly. Eotaxin mRNA accumulation was also prevented in these animals, We conclude that neonatal exposure to a single MHC class 11 alloantigen is sufficient to elicit an IL-4-dependent hypereosinophilic syndrome mimicking the lymphocytic variant of this disorder in humans.
E-info
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