Title
A role for eosinophils in transplant rejection A role for eosinophils in transplant rejection
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Oxford ,
Subject
Human medicine
Source (journal)
Trends in immunology. - Oxford
Volume/pages
22(2001) :5 , p. 247-251
ISSN
1471-4906
ISI
000169936400010
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Eosinophils release inflammatory mediators and cationic proteins that are instrumental in the pathogenesis of allergic diseases such as bronchial asthma. Here, we review experimental observations indicating that eosinophils are also involved in the rejection of a allografts. We pro pose that their role as effectors of transplant damage becomes crucial when classical pathways of rejection are inhibited and T helper 2 (Th2) cells dominate the alloimmune response.
E-info
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