Experience with the Wujciak-Opelz allocation system in a single center : an increase in HLA-DR mismatching and in early occurring acute rejection episodes

Vereerstraeten, P.; Abramowicz, D.; De Pauw, L.; Kinnaert, P.

doi:10.1111/J.1432-2277.1998.TB00821.X

Title

Experience with the Wujciak-Opelz allocation system in a single center : an increase in HLA-DR mismatching and in early occurring acute rejection episodes

Author

Vereerstraeten, P.

Abramowicz, D.

De Pauw, L.

Kinnaert, P.

Abstract

The present single-center, retrospective study was undertaken to assess the impact of the Wujciak-Opelz allocation system (XCOMB), currently used within Eurotransplant for renal allografts, on the incidence of early occurring rejection episodes (RE). Implementation of the system resulted in an increase of HLA-DR mismatches (MM), while the incidence of HLA-A + B + DR MM remained unchanged. During the Ist post-transplant month, the total number of RE, expressed per patient-months, increased by 64 % (0.326 vs 0.199, P = 0.007); when considering only severe and irreversible RE, the increase was 76 % (0.158 vs 0.090, P = 0.011). In contrast, from the 2nd to the 12th posttransplant month, the incidence of RE, regardless of severity, was similar before and after implementation of XCOMB. As early occurring RE have detrimental effects on longterm graft: outcome, these observations, if confirmed on a larger scale, would justify changes in the allocation algorithm.

Language

English

Source (journal)

Transplant international. - Heidelberg, 1988

Publication

Heidelberg : 1998

ISSN

0934-0874 [print]

1432-2277 [online]

DOI

10.1111/J.1432-2277.1998.TB00821.X

10.1007/S001470050161