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Title
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Cutting edge : CD40 ligation prevents neonatal induction of transplantation tolerance
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Author
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Abstract
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| To investigate the consequences of CD40 engagement on the neonatal induction of transplantation tolerance, BALB/c mice were injected at birth with (A/J x BALB/c) F-1 spleen cells together with activating anti-CD40 mAb and grafted 4 wk later with A/J skin. Whereas A/J allografts were accepted in mice neonatally injected with F-1 cells and control Ab, they were acutely rejected in mice injected with F-1 cells and anti-CD40 mAb, Neonatal administration of anti-CD40 mAb resulted in enhanced anti-A/J CTL activity, increased IFN-gamma, and decreased IL-4 production by donor-specific T cells in vitro. Experiments using anti-cytokine mAb and IFN-gamma-deficient mice demonstrated that CD40 ligation prevents neonatal allotolerance through an IFN-gamma- and IL-12-dependent pathway. Finally, we found that newborn T cells express less CD40L than adult T cells upon TCR engagement. Taken together these data indicate that insufficiency of CD40/CD40L interactions contribute to neonatal transplantation tolerance. |
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Language
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English
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Source (journal)
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The journal of immunology. - Baltimore, Md
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Publication
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Baltimore, Md
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1998
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ISSN
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0022-1767
[Print]
1550-6606
[Online]
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Volume/pages
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160
:10
(1998)
, p. 4666-4669
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ISI
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000073500000003
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