Publication
Title
Cutting edge : CD40 ligation prevents neonatal induction of transplantation tolerance
Author
Abstract
To investigate the consequences of CD40 engagement on the neonatal induction of transplantation tolerance, BALB/c mice were injected at birth with (A/J x BALB/c) F-1 spleen cells together with activating anti-CD40 mAb and grafted 4 wk later with A/J skin. Whereas A/J allografts were accepted in mice neonatally injected with F-1 cells and control Ab, they were acutely rejected in mice injected with F-1 cells and anti-CD40 mAb, Neonatal administration of anti-CD40 mAb resulted in enhanced anti-A/J CTL activity, increased IFN-gamma, and decreased IL-4 production by donor-specific T cells in vitro. Experiments using anti-cytokine mAb and IFN-gamma-deficient mice demonstrated that CD40 ligation prevents neonatal allotolerance through an IFN-gamma- and IL-12-dependent pathway. Finally, we found that newborn T cells express less CD40L than adult T cells upon TCR engagement. Taken together these data indicate that insufficiency of CD40/CD40L interactions contribute to neonatal transplantation tolerance.
Language
English
Source (journal)
The journal of immunology. - Baltimore, Md
Publication
Baltimore, Md : 1998
ISSN
0022-1767 [Print]
1550-6606 [Online]
Volume/pages
160:10(1998), p. 4666-4669
ISI
000073500000003
UAntwerpen
Faculty/Department
[E?say:metaLocaldata.cgzprojectinf]
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 06.01.2015
Last edited 08.11.2017