Title
IL-12 prevents neonatal induction of transplantation tolerance in mice IL-12 prevents neonatal induction of transplantation tolerance in mice
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Weinheim ,
Subject
Human medicine
Source (journal)
European journal of immunology. - Weinheim
Volume/pages
28(1998) :4 , p. 1426-1430
ISSN
0014-2980
ISI
000073099900033
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
We investigated the effect of IL-12 on the induction of transplantation tolerance by neonatal injection of allogenic cells. We first observed that injection of newborn BALB/c mice with IL-12 and (A/J x BALB/c)F1 spleen cells prevented the Th2 alloimmune response induced by neonatal inoculation of F1 cells alone and allowed the differentiation of T cells secreting high amounts of IL-2 and IFN-gamma in mixed lymphocyte cultures with donor-type stimulators. Furthermore, IL-12 administration resulted in the emergence of anti-donor cytotoxic T lymphocyte responses although at lower levels than in central uninjected mice. In parallel, we found that mice injected at birth with IL-12 and F1 cells did not develop chimerism and were able to reject a donor-type skin graft as efficiently as control mice. We conclude that IL-12 inhibits the Th2 polarization of the newborn response to alloantigens and prevents thereby the establishment of transplantation tolerance.
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