|
Title
|
|
|
|
IL-12 prevents neonatal induction of transplantation tolerance in mice
|
|
|
Author
|
|
|
|
|
|
|
Abstract
|
|
|
|
| We investigated the effect of IL-12 on the induction of transplantation tolerance by neonatal injection of allogenic cells. We first observed that injection of newborn BALB/c mice with IL-12 and (A/J x BALB/c)F1 spleen cells prevented the Th2 alloimmune response induced by neonatal inoculation of F1 cells alone and allowed the differentiation of T cells secreting high amounts of IL-2 and IFN-gamma in mixed lymphocyte cultures with donor-type stimulators. Furthermore, IL-12 administration resulted in the emergence of anti-donor cytotoxic T lymphocyte responses although at lower levels than in central uninjected mice. In parallel, we found that mice injected at birth with IL-12 and F1 cells did not develop chimerism and were able to reject a donor-type skin graft as efficiently as control mice. We conclude that IL-12 inhibits the Th2 polarization of the newborn response to alloantigens and prevents thereby the establishment of transplantation tolerance. |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
European journal of immunology. - Weinheim
|
|
|
Publication
|
|
|
|
Weinheim
:
1998
|
|
|
ISSN
|
|
|
|
0014-2980
|
|
|
DOI
|
|
|
|
10.1002/(SICI)1521-4141(199804)28:04<1426::AID-IMMU1426>3.0.CO;2-P
|
|
|
Volume/pages
|
|
|
|
28
:4
(1998)
, p. 1426-1430
|
|
|
ISI
|
|
|
|
000073099900033
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|