Title
Hypercalcemia complicating systemic oxalosis in primary hyperoxaluria type-1 Hypercalcemia complicating systemic oxalosis in primary hyperoxaluria type-1
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Oxford :Oxford univ press united kingdom ,
Subject
Human medicine
Source (journal)
Nephrology, dialysis, transplantation. - Berlin
Source (book)
3rd Workshop on Primary Hyperoxaluria, OCT 21-22, 1994, LYON, FRANCE
Volume/pages
10(1995) :s:[8] , p. 17-21
ISSN
0931-0509
ISI
A1995TD35800006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Persistent hypercalcaemia was observed in two patients with oxalate osteopathy complicating primary hyperoxaluria type 1; four other cases have been reported in the literature. In none of the six patients could hypercalcaemia be ascribed to hyperparathyroidism secondary to renal failure. It occurred in the absence of aluminium intoxication, and was associated with normal calcitriol. Hypercalcaemia responded to mithramycin in one patient, and to corticosteroid administration in three; corticosteroid withdrawal was followed by recurrence of hypercalcaemia in the three cases. It is suggested that hypercalcaemia results from the osteoclast-stimulating activity of macrophages constituting the granulomata which invade the bone marrow in response to oxalate deposition. Whatever its pathogenesis, a trial of corticosteroid appears warranted for treating hypercalcaemia complicating oxalosis.
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