Publication
Title
Hypercalcemia complicating systemic oxalosis in primary hyperoxaluria type-1
Author
Abstract
Persistent hypercalcaemia was observed in two patients with oxalate osteopathy complicating primary hyperoxaluria type 1; four other cases have been reported in the literature. In none of the six patients could hypercalcaemia be ascribed to hyperparathyroidism secondary to renal failure. It occurred in the absence of aluminium intoxication, and was associated with normal calcitriol. Hypercalcaemia responded to mithramycin in one patient, and to corticosteroid administration in three; corticosteroid withdrawal was followed by recurrence of hypercalcaemia in the three cases. It is suggested that hypercalcaemia results from the osteoclast-stimulating activity of macrophages constituting the granulomata which invade the bone marrow in response to oxalate deposition. Whatever its pathogenesis, a trial of corticosteroid appears warranted for treating hypercalcaemia complicating oxalosis.
Language
English
Source (journal)
Nephrology, dialysis, transplantation. - Berlin
Source (book)
3rd Workshop on Primary Hyperoxaluria, OCT 21-22, 1994, LYON, FRANCE
Publication
Oxford : Oxford univ press united kingdom, 1995
ISSN
0931-0509
Volume/pages
10:s:[8](1995), p. 17-21
ISI
A1995TD35800006
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
[E?say:metaLocaldata.cgzprojectinf]
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 06.01.2015
Last edited 02.08.2017