Title
Insulin-like growth factor-i values in patients on maintenance hemodialysis : relationship to growth-hormone and albumin levels Insulin-like growth factor-i values in patients on maintenance hemodialysis : relationship to growth-hormone and albumin levels
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Milano ,
Subject
Human medicine
Source (journal)
Journal of endocrinological investigation. - Milano
Volume/pages
16(1993) :9 , p. 691-696
ISSN
0391-4097
ISI
A1993MF94800007
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Twenty-seven uremic patients (blood urea: 58.2+/-2.2 mmol/l; blood creatinine: 1,069+/-53 mumol/l; mean+/-SE) on maintenance dialysis were investigated immediately before and after a dialysis session. Control data were obtained from 30 normal volunteers. Before dialysis, circulating levels of insulin-like growth factor I (IGF-I) were similar in anuric and nonanuric patients, averaging 305+/-24 mug/l, a value not different from that observed in normal controls (262+/-16 mug/l). IGF-I levels were not modified by dialysis. In contrast, GH values were significantly higher in uremic patients (3.6+/-0.6 mug/l) than in normal controls (2.5+/-0.5 mug/l) and decreased significantly after the dialysis session (0.8+/-0.1 mug/l). IGF-I values were positively correlated with GH and albumin, but not with the various parameters of renal insufficiency, suggesting that in chronic renal failure, synthesis of IGF-I appears to be regulated, as in normal subjects, by growth hormone and nutritional status.
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