Title
The long-term effects of prophylactic okt3 monoclonal-antibody in cadaver kidney-transplantation : a single-center, prospective, randomized study The long-term effects of prophylactic okt3 monoclonal-antibody in cadaver kidney-transplantation : a single-center, prospective, randomized study
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Baltimore, Md ,
Subject
Human medicine
Source (journal)
Transplantation. - Baltimore, Md, 1963, currens
Volume/pages
54(1992) :3 , p. 433-437
ISSN
0041-1337
ISI
A1992JP01800009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
We conducted a randomized, prospective study to determine the long-term effects of prophylactic OKT3 in cadaveric renal transplantation. In the first group of patients (n=56) OKT3 (5 mg/day) was administered for the first 14 postoperative days in association with azathioprine (AZA) and low-dose steroids, cyclosporine (CsA) being introduced on day 11. The other group of patients (n=52) received CsA from the first POD, together with AZA and steroids. Both protocols were identical from POD 14 on. The total number of infections was higher in OKT3 patients (124/1455 patient-months [P-M] vs. 68/1320 in CsA patients, P<0.001) without impact on patient survival (94.5% in OKT3 vs. 93% in CsA patients). OKT3 patients experienced a lower number of rejection episodes (61 per 1455 P-M of risk exposure vs. 81/1320 in CsA patients, P<0.05). In addition, the frequency of corticoresistant rejection episodes was lower in OKT3 patients (9 out of 61 vs. 24 out of 81 in CsA patients, P<0.05). This resulted in a trend toward improved overall graft survival (83% vs. 75%, P=0.12) and in a significant increase in immunological graft survival (92% vs. 79%, P=0.02) in OKT3 patients at 3 years. Taken together, these data suggest that prophylactic OKT3 therapy might have long-term beneficial effects in cadaveric renal transplantation.
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