Title
Sulfadiazine-induced obstructive renal-failure in a kidney-transplant recipient Sulfadiazine-induced obstructive renal-failure in a kidney-transplant recipient
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New York ,
Subject
Human medicine
Source (journal)
Clinical transplantation. - New York
Volume/pages
6(1992) :31 , p. 191-193
ISSN
0902-0063
ISI
A1992JB84900009
Carrier
E
Target language
English (eng)
Abstract
A kidney transplant recipient on long-term sulfadiazine and pyrimethamine therapy for recurrent toxoplasmosis chorioretinitis developed acute oliguric renal failure. Ultrasound examination of the graft revealed hydronephrosis caused by radiolucent calculi. The calculi were most probably made of sulfadiazine, as sulfadiazine crystalluria was detected on several occasions prior to the acute obstruction. Although percutaneous nephrostomy was temporarily required, withdrawal of sulfadiazine and alkalinization of the urine led to a prompt dissolution of the calculi. The risks factors and therapeutic measures of sulfadiazine-induced obstructive nephropathy are reviewed.
E-info
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