Sulfadiazine-induced obstructive renal-failure in a kidney-transplant recipientSulfadiazine-induced obstructive renal-failure in a kidney-transplant recipient
Faculty of Medicine and Health Sciences
1992New York, 1992
Clinical transplantation. - New York
6(1992):31, p. 191-193
A kidney transplant recipient on long-term sulfadiazine and pyrimethamine therapy for recurrent toxoplasmosis chorioretinitis developed acute oliguric renal failure. Ultrasound examination of the graft revealed hydronephrosis caused by radiolucent calculi. The calculi were most probably made of sulfadiazine, as sulfadiazine crystalluria was detected on several occasions prior to the acute obstruction. Although percutaneous nephrostomy was temporarily required, withdrawal of sulfadiazine and alkalinization of the urine led to a prompt dissolution of the calculi. The risks factors and therapeutic measures of sulfadiazine-induced obstructive nephropathy are reviewed.