Title
Induction of interleukin-6 and interleukin-10 by the okt3 monoclonal-antibody : possible relevance to posttransplant lymphoproliferative disorders Induction of interleukin-6 and interleukin-10 by the okt3 monoclonal-antibody : possible relevance to posttransplant lymphoproliferative disorders
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Copenhagen :Munksgaard int publ ltd ,
Subject
Human medicine
Source (journal)
Clinical transplantation. - New York
Source (book)
SYMP ON IMMUNOSUPPRESSION AND LYMPHOPROLIFERATIVE DISORDERS, JUN 07, 1991, CINCINNATI, OH
Volume/pages
6(1992) :32 , p. 265-268
ISSN
0902-0063
ISI
A1992JB85100012
Carrier
E
Target language
English (eng)
Abstract
Before exerting its potent immunosuppressive properties, the OKT3 monoclonal antibody induces the activation of T cells and monocytic cells. In this paper, we present evidence that this activation step results in the release of interleukin-6 (IL-6) and interleukin-10 (IL-10). Since IL-6 favors the outgrowth of Epstein-Barr virus (EBV)-infected cells and IL-10 impairs the T-cell defences against EBV, we suggest that these cytokines could be involved in the pathogenesis of EBV-associated lymphoproliferative disorders developing in transplant patients receiving multiple courses of OKT3.
E-info
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