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Title
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Induction of interleukin-6 and interleukin-10 by the okt3 monoclonal-antibody : possible relevance to posttransplant lymphoproliferative disorders
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Author
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Abstract
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| Before exerting its potent immunosuppressive properties, the OKT3 monoclonal antibody induces the activation of T cells and monocytic cells. In this paper, we present evidence that this activation step results in the release of interleukin-6 (IL-6) and interleukin-10 (IL-10). Since IL-6 favors the outgrowth of Epstein-Barr virus (EBV)-infected cells and IL-10 impairs the T-cell defences against EBV, we suggest that these cytokines could be involved in the pathogenesis of EBV-associated lymphoproliferative disorders developing in transplant patients receiving multiple courses of OKT3. |
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Language
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English
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Source (journal)
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Clinical transplantation. - New York
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Source (book)
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SYMP ON IMMUNOSUPPRESSION AND LYMPHOPROLIFERATIVE DISORDERS, JUN 07, 1991, CINCINNATI, OH
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Publication
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Copenhagen
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Munksgaard int publ ltd
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1992
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ISSN
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0902-0063
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Volume/pages
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6
:32
(1992)
, p. 265-268
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ISI
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A1992JB85100012
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