Publication
Title
Induction of interleukin-6 and interleukin-10 by the okt3 monoclonal-antibody : possible relevance to posttransplant lymphoproliferative disorders
Author
Abstract
Before exerting its potent immunosuppressive properties, the OKT3 monoclonal antibody induces the activation of T cells and monocytic cells. In this paper, we present evidence that this activation step results in the release of interleukin-6 (IL-6) and interleukin-10 (IL-10). Since IL-6 favors the outgrowth of Epstein-Barr virus (EBV)-infected cells and IL-10 impairs the T-cell defences against EBV, we suggest that these cytokines could be involved in the pathogenesis of EBV-associated lymphoproliferative disorders developing in transplant patients receiving multiple courses of OKT3.
Language
English
Source (journal)
Clinical transplantation. - New York
Source (book)
SYMP ON IMMUNOSUPPRESSION AND LYMPHOPROLIFERATIVE DISORDERS, JUN 07, 1991, CINCINNATI, OH
Publication
Copenhagen : Munksgaard int publ ltd, 1992
ISSN
0902-0063
Volume/pages
6:32(1992), p. 265-268
ISI
A1992JB85100012
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 06.01.2015
Last edited 05.04.2017