Induction of interleukin-6 and interleukin-10 by the okt3 monoclonal-antibody : possible relevance to posttransplant lymphoproliferative disorders
Faculty of Medicine and Health Sciences
Copenhagen :Munksgaard int publ ltd
Clinical transplantation. - New York
SYMP ON IMMUNOSUPPRESSION AND LYMPHOPROLIFERATIVE DISORDERS, JUN 07, 1991, CINCINNATI, OH
, p. 265-268
Before exerting its potent immunosuppressive properties, the OKT3 monoclonal antibody induces the activation of T cells and monocytic cells. In this paper, we present evidence that this activation step results in the release of interleukin-6 (IL-6) and interleukin-10 (IL-10). Since IL-6 favors the outgrowth of Epstein-Barr virus (EBV)-infected cells and IL-10 impairs the T-cell defences against EBV, we suggest that these cytokines could be involved in the pathogenesis of EBV-associated lymphoproliferative disorders developing in transplant patients receiving multiple courses of OKT3.