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Title
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Detrimental role of donor-recipient HLA-DQ5 and HLA-DQ6 disparities on cadaver kidney graft-survival
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Author
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Abstract
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| Donor-recipient incompatibility (D + R-) for HLA-DQ1, but not for -DQ2 or -DQ3, is associated with an adverse effect on cadaver kidney graft survival. Until now, however, DQ1 recipients of DQ1-negative kidneys (D - R+) have not been differentiated from DQ1-identical donor-recipient pairs (D + R+) and splits of DQ1, DQ5 and DQ6, have not been studied in that respect. From our data (480 transplantations performed from January 1980 to December 1990), three donor-recipient DQ combinations (D + R+, D - R+, D + R-) were formed for each of four DQ specificities (DQ2, DQ3, DQ5, DQ6). As DR-DQ linkage disequilibrium is well conserved in caucasoid individuals, DQ specificities were inferred from the associated DR specificities. Graft survival rate (%) was significantly lower for the DQ5 D + R- and the DQ6 D - R+ combinations when compared with the other corresponding DQ combinations, whereas no significant difference was observed between the DQ2 and DQ3 combinations. In conclusion, if DQ1 plays a prominent role in kidney graft survival, the effects of its splits appear dissociated: DQ5 could be a marker of high antigenicity and DQ6 a marker of high responsiveness. |
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Language
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English
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Source (journal)
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Transplant international. - Heidelberg, 1988
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Source (book)
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5TH CONGRESS OF THE EUROPEAN SOC FOR ORGAN TRANSPLANTATION, OCT 07-10, 1991, MAASTRICHT, NETHERLANDS
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Publication
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New york
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Springer verlag
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1992
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ISSN
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0934-0874
[print]
1432-2277
[online]
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Volume/pages
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5
:s:[1]
(1992)
, p. S143-S145
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ISI
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A1992JV18900045
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