Publication
Title
5-O-Demethylnobiletin, a polymethoxylated flavonoid, from **Citrus depressa** Hayata peel prevents protein glycation
Author
Abstract
Advanced glycation end products (AGEs) have been implicated in many age-related chronic diseases and the search for AGEs has intensified. In the present study, eight Okinawan edible or medicinal plants were screened for the anti-glycation activity. A known polymethoxylated flavonoid, 5-O-demethyl nobiletin (DN), was isolated from the chloroform fraction of Citrus depressa Hayata (Rutaceae) and was identified for the first time as an AGEs inhibitor. DN prevented protein glycation significantly better than aminoguanidine (AG) with the respective IC50 values of 64.2 and 484.3 µM (p = 0.01). Further studies revealed that DN prevented AGEs formation predominantly by inhibiting fructosamine adduct formation while only partly by preventing dicarbonyl generation. Together, these results suggest that further exploration on the identification of AGEs inhibitors from Okinawan plants and in-depth investigations on the AGEs inhibitions by polymethoxylated flavonoids are required.
Language
English
Source (journal)
Journal of functional foods. - -
Publication
2014
ISSN
1756-4646
Volume/pages
11(2014), p. 243-249
ISI
000346885500026
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 12.01.2015
Last edited 18.07.2017
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