Title
Ethnobotanical survey, antimicrobial and anticomplement activities of Guinean medicinal plants traditionally used in the treatment of inflammatory diseases in Conakry and Dubreka Ethnobotanical survey, antimicrobial and anticomplement activities of Guinean medicinal plants traditionally used in the treatment of inflammatory diseases in Conakry and Dubreka
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Subject
Pharmacology. Therapy
Source (journal)
Journal of plant sciences
Volume/pages
3(2015) :1/2 , p. 11-19
ISSN
2331-0723
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Based on an ethnobotanical survey related to inflammatory diseases, 67Guinean plant species belonging to 35 botanical families were inventoried. Some plant species frequently used in the treatment of rheumatism, skin diseases and microbial infections were selected and submitted to a biological investigation including antimicrobial and anticomplement activities. At a concentration of 1mg/ml, all the tested extracts were devoid of any activity against the tested fungi viz Candida albicans, Aspergillus niger, and Trichophyton rubrum and showed a cytotoxicity varying from 0.25 to 500 μg/ml which prevented the evaluation of possible antiviral effects against herpes simplexvirus type 1, Coxsackie-B2, Measle Edmondston A, Poliomyelitis virus type 1, Semliki forest L10 and Vesicular stomatitis virus for viruses. At 1mg/ml, only the extracts ofAgeratum conyzoides, Alchornea cordifolia, Acanthospermum hispidum, Erythrina senegalensis, Harungana madagascariensis, Hymenocardia acida, and Lophira alata showed an antibacterial effect against Bacillus cereus and/or Staphylococcus aureus. All the tested extracts exhibited an inhibitory effect on the Alternative Complement Pathway complement except for Bambusa vulgaris. Only the extracts of Ageratum conyzoides and Hymenocardia acida interfered with both activation pathways of the complement system. The results of the present work support the anti-inflammatory traditional use of some selected plant species which could be explained, at least partly, by their anticomplement properties.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/186cba/b93ef087.pdf
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