Title
Ethnomedical, phytochemical and biological investigations of **Margaritaria discoidea** (Baill.) Webster, a plant species widely used in Guinean traditional medicine Ethnomedical, phytochemical and biological investigations of **Margaritaria discoidea** (Baill.) Webster, a plant species widely used in Guinean traditional medicine
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Subject
Pharmacology. Therapy
Source (journal)
Journal of plant sciences
Volume/pages
3(2015) :1/2 , p. 40-46
ISSN
2331-0723
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
From an ethnomedical survey conducted in Conakry and Dubreka (Guinea), 12 traditional healers and 10 herbalists were interviewed. Their knowledge and experience along with the traditional uses of Margaritaria discoidea (euphorbiaceae) were recorded. The fractionation and purification of the leaf extract led to the isolation of a series of securinane-type alkaloids including the known ent-Phyllanthidine, 14,15-dihydroallosecurinine-15-β-ol, securinine, securinol, and viroallosecurinine. Their structures were elucidated on the basis of 1H and 13C-NMR data and comparison with published spectra. The biological activities of the methanol and chloroform leaf extracts along with the alkaloids Y were evaluated against Escherichia coli, Staphylococcus aureus, Candida albicans, Mycobacterium chelonae, the protozoa Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei brucei,and Trypanosoma cruzi and/or HIV1 and 2. Although weak to moderate, these biological findings support partly the wide traditional use of Margaritaria discoidea.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/efd5a1/5479540d.pdf
Handle