|
Title
|
|
|
|
Cognitive, neuropsychiatric, and motor features associated with apolipoprotein E epsilon 4 allele in a sample of Bulgarian patients with late-onset Parkinson's disease
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Objective: To evaluate the role of apolipoprotein E (APOE) 4 allele on cognitive, neuropsychiatric, and motor features in a sample of Bulgarian patients with late-onset Parkinson's disease (LOPD, age at onset > 55 years). Methods: A total of 16 patients with LOPD having APOE 3/4 genotype were compared to 30 patients with LOPD having APOE 3/3 genotype and 20 healthy control individuals. Detailed cognitive assessment and evaluation of neuropsychiatric and motor symptoms were performed. Results: The patients with LOPD had significantly lower scores in all cognitive domains compared to controls. The patients with LOPD carrying an 4 allele showed some significant differences in their cognitive, motor, and neuropsychiatric features. Conclusions: The data suggest a role of the APOE genotype as a disease-modifying factor. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
American journal of Alzheimer's disease and other dementias. - Place of publication unknown
| |
|
Publication
|
|
|
|
Place of publication unknown
:
2014
| |
|
ISSN
|
|
|
|
1533-3175
| |
|
DOI
|
|
|
|
10.1177/1533317514525655
| |
|
Volume/pages
|
|
|
|
29
:7
(2014)
, p. 614-619
| |
|
ISI
|
|
|
|
000344681100008
| |
|
Pubmed ID
|
|
|
|
24646656
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|