Title
Cognitive, neuropsychiatric, and motor features associated with apolipoprotein E epsilon 4 allele in a sample of Bulgarian patients with late-onset Parkinson's disease
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
,
Subject
Human medicine
Source (journal)
American journal of Alzheimer's disease and other dementias. - Place of publication unknown
Volume/pages
29(2014) :7 , p. 614-619
ISSN
1533-3175
ISI
000344681100008
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Objective: To evaluate the role of apolipoprotein E (APOE) 4 allele on cognitive, neuropsychiatric, and motor features in a sample of Bulgarian patients with late-onset Parkinson's disease (LOPD, age at onset > 55 years). Methods: A total of 16 patients with LOPD having APOE 3/4 genotype were compared to 30 patients with LOPD having APOE 3/3 genotype and 20 healthy control individuals. Detailed cognitive assessment and evaluation of neuropsychiatric and motor symptoms were performed. Results: The patients with LOPD had significantly lower scores in all cognitive domains compared to controls. The patients with LOPD carrying an 4 allele showed some significant differences in their cognitive, motor, and neuropsychiatric features. Conclusions: The data suggest a role of the APOE genotype as a disease-modifying factor.
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