Title
Molecular mechanisms underlying the role of microRNAs in the chemoresistance of pancreatic cancer Molecular mechanisms underlying the role of microRNAs in the chemoresistance of pancreatic cancer
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New york :Hindawi publishing corporation ,
Subject
Biology
Human medicine
Engineering sciences. Technology
Source (journal)
BioMed research international
Volume/pages
(2014) , 17 p.
ISSN
2314-6133
2314-6141
2314-6133
Article Reference
678401
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is an extremely severe disease where the mortality and incidence rates are almost identical. This is mainly due to late diagnosis and limited response to current treatments. The tumor macroenvironment/microenvironment have been frequently reported as the major contributors to chemoresistance in PDAC, preventing the drugs from reaching their intended site of action (i. e., the malignant duct cells). However, the recent discovery of microRNAs (miRNAs) has provided new directions for research on mechanisms underlying response to chemotherapy. Due to their tissue-/disease-specific expression and high stability in tissues and biofluids, miRNAs represent new promising diagnostic and prognostic/predictive biomarkers and therapeutic targets. Furthermore, several studies have documented that selected miRNAs, such as miR-21 and miR-34a, may influence response to chemotherapy in several tumor types, including PDAC. In this review, we summarize the current knowledge on the role of miRNAs in PDAC and recent advances in understanding their role in chemoresistance through multiple molecular mechanisms.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/729b14/9451.pdf
E-info
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