Title
Development and application of a non-targeted extraction method for the analysis of migrating compounds from plastic baby bottles by GC-MS Development and application of a non-targeted extraction method for the analysis of migrating compounds from plastic baby bottles by GC-MS
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Abingdon ,
Subject
Chemistry
Pharmacology. Therapy
Source (journal)
EXPOSURE & RISK ASSESSMENT
Food additives and contaminants : part A : chemistry, analysis, control, exposure and risk assessment. - Abingdon
Volume/pages
31(2014) :12 , p. 2090-2102
ISSN
1944-0049
ISI
000345441700019
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
In 2011, the European Union prohibited the production of polycarbonate (PC) baby bottles due to the toxic effects of the PC monomer bisphenol-A. Therefore, baby bottles made of alternative materials, e.g. polypropylene (PP) or polyethersulphone (PES), are currently marketed. The principal aim of the study was the identification of major compounds migrating from baby bottles using a liquid-liquid extraction followed by GC/MS analysis. A 50% EtOH in water solution was selected as a simulant for milk. After sterilisation of the bottle, three migration experiments were performed during 2h at 70 degrees C. A non-targeted liquid-liquid extraction with ethyl acetate-n-hexane (1:1) was performed on the simulant samples. Identification of migrants from 24 baby bottles was done using commercially available WILEY and NIST mass spectra libraries. Differences in the migrating compounds and their intensities were observed between the different types of plastics, but also between the same polymer from a different producer. Differences in the migration patterns were perceived as well between the sterilisation and the migrations and within the different migrations. Silicone, Tritan (TM) and PP exhibited a wide variety of migrating compounds, whereas PES and polyamide (PA) showed a lower amount of migrants, though sometimes in relatively large concentrations (azacyclotridecan-2-one up to 250 mu gkg(-1)). Alkanes (especially in PP bottles), phthalates (dibutylphthalate in one PP bottle (+/- 40 mu gkg(-1)) and one silicone bottle (+/- 25 mu gkg(-1)); diisobutylphthalate in one PP (+/- 10 mu gkg(-1)), silicone (up to +/- 80 mu gkg(-1)); and Tritan (TM) bottle (+/- 30 mu gkg(-1))), antioxidants (Irgafos 168, degradation products of Irganox 1010 and Irganox 1076), etc. were detected for PP, silicone and Tritan (TM) bottles. Although the concentrations were relatively low, some compounds not authorised by European Union Regulation No. 10/2011, such as 2,4-di-tert-butylphenol (10-100 mu gkg(-1)) or 2-butoxyethyl acetate (about 300 mu gkg(-1)) were detected. Migrating chemicals were identified as confirmed (using a standard) or as tentative (further confirmation required).
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