Publication
Title
Insights into GABA(A)ergic system deficits in fragile X syndrome lead to clinical trials
Author
Abstract
An increasing number of studies implicate the GABA(A)ergic system in the pathophysiology of the fragile X syndrome, a frequent cause of intellectual disability and autism. Animal models have proven invaluable in unravelling the molecular mechanisms underlying the disorder. Multiple defects in this inhibitory system have been identified in Fmr1 knockout mice, including altered expression of various components, aberrant GABA(A) receptor-mediated signalling, altered GABA concentrations and anatomical defects in GABAergic neurons. Aberrations compatible with those described in the mouse model were detected in dfmr1 deficient Drosophila melanogaster, a validated fly model for the fragile X syndrome. Treatment with drugs that ameliorate the GABA(A)ergic deficiency in both animal models have demonstrated that the GABA(A) receptor is a promising target for the treatment of fragile X patients. Based on these preclinical studies, clinical trials in patients have been initiated. (C) 2014 Elsevier Ltd. All rights reserved.
Language
English
Source (journal)
Neuropharmacology. - Oxford, 1970, currens
Publication
Oxford : Pergamon-elsevier science ltd, 2015
ISSN
0028-3908 [print]
1873-7064 [online]
Volume/pages
88(2015), p. 48-54
ISI
000345949500006
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 13.01.2015
Last edited 05.11.2017
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