Publication
Title
Flow and volume dependence of respiratory mechanical properties studied by forced oscillation
Author
Abstract
The influence of inspiratory and expiratory flow magnitude, lung volume, and lung volume history on respiratory system properties was studied by measuring transfer impedances (4-30 Hz) in seven normal subjects during various constant flow maneuvers. The measured impedances were analyzed with a six-coefficient model including airway resistance (Raw) and inertance (Iaw), tissue resistance (Rti), inertance (Iti), and compliance (Cti), and alveolar gas compressibility. Increasing respiratory flow from 0.1 to 0.4 1/s was found to increase inspiratory and expiratory Raw by 63% and 32%, respectively, and to decrease Iaw, but did not change tissue properties. Raw, Iti, and Cti were larger and Rti was lower during expiration than during inspiration. Decreasing lung volume from 70 to 30% of vital capacity increased Raw by 80%. Cti was larger at functional residual capacity than at the volume extremes. Preceding the measurement by a full expiration rather than by a full inspiration increased Iaw by 15%. The data suggest that the determinants of Raw and Iaw are not identical, that airway hysteresis is larger than lung hysteresis, and that respiratory muscle activity influences tissue properties.
Language
English
Source (journal)
Journal of applied physiology / American Physiological Society. - Washington, D.C.
Publication
Washington, D.C. : 1989
ISSN
8750-7587
Volume/pages
67:6(1989), p. 2212-2218
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
External links
Record
Identification
Creation 16.01.2015
Last edited 19.11.2015