Title
Porcine reproductive and respiratory syndrome virus entry into the porcine macrophage Porcine reproductive and respiratory syndrome virus entry into the porcine macrophage
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
London ,
Subject
Biology
Human medicine
Engineering sciences. Technology
Source (journal)
Journal of general virology. - London
Volume/pages
91(2010) :7 , p. 1659-1667
ISSN
0022-1317
ISI
000279747600001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) emerged in the late 1980s and rapidly became one of the most significant viral pathogens in the swine industry. In vivo, the virus shows a very narrow cell tropism and targets specific subsets of porcine macrophages. The entry of PRRSV into its host cell is the first crucial step in infection and has been the focus of many fundamental studies. This review provides a comprehensive overview of the current knowledge on PRRSV entry into the porcine macrophage, covering virus binding, internalization and genome release, and integrates these findings into a general model of the entry process.
E-info
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