Genetics of sudden cardiac death in the youngGenetics of sudden cardiac death in the young
Faculty of Medicine and Health Sciences
Translational Pathophysiological Research (TPR)
Medical Genetics (MEDGEN)
Clinical genetics. - Copenhagen
88(2015):2, p. 101-113
University of Antwerp
Sudden cardiac death (SCD) has an enormous impact on those who are left behind, evoking strong feelings of anxiety and incomprehension because such a dramatic event was not anticipated. Moreover, over the last decade a prominent genetic contribution to the pathogenesis of SCD has been unveiled. As many inherited cardiac diseases show an autosomal dominant pattern of inheritance, the risk of carrying the same inherited predisposition is a real concern for the relatives. In this article, we discuss the major causes of primary electrical disorders, cardiomyopathies and thoracic aortic dissection and address issues in genotypephenotype correlation, personalized management and cardiogenetic counselling.