Title
Poly(I:C) as cancer vaccine adjuvant : knocking on the door of medical breakthroughs Poly(I:C) as cancer vaccine adjuvant : knocking on the door of medical breakthroughs
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Oxford :Pergamon-elsevier science ltd ,
Subject
Pharmacology. Therapy
Human medicine
Source (journal)
Pharmacology and therapeutics. - Oxford
Volume/pages
146(2015) , p. 120-131
ISSN
0163-7258
ISI
000349504500009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Although cancer vaccination has yielded promising results in patients, the objective response rates are low. The right choice of adjuvant might improve the efficacy. Here, we review the biological rationale, as well as the preclinical and clinical results of polyinosinic:polycytidylic acid and its derivative poly-ICLC as cancer vaccine adjuvants. These synthetic immunological danger signals enhanced vaccine-induced anti-tumor immune responses and contributed to tumor elimination in animal tumor models and patients. Supported by these results, poly-ICLC-containing cancer vaccines are currently extensively studied in the ongoing trials, making it highly plausible that poly-ICLC will be part of the future approved cancer immunotherapies.
E-info
https://repository.uantwerpen.be/docman/iruaauth/d1020c/df045be8b0b.pdf
Full text (open access)
https://repository.uantwerpen.be/docman/irua/00514c/9569.pdf
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