Title
Gairo virus, a novel arenavirus of the widespread **Mastomys natalensis** : genetically divergent, but ecologically similar to Lassa and Morogoro viruses Gairo virus, a novel arenavirus of the widespread **Mastomys natalensis** : genetically divergent, but ecologically similar to Lassa and Morogoro viruses
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
New York ,
Subject
Biology
Human medicine
Source (journal)
Virology. - New York
Volume/pages
476(2015) , p. 249-256
ISSN
0042-6822
ISI
000349883000029
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Despite its near pan-African range, the Natal multimammate mouse, Mastomys natalensis, carries the human pathogen Lassa virus only in West Africa, while the seemingly non-pathogenic arenaviruses Mopeia, Morogoro, and Luna have been detected in this semi-commensal rodent in Mozambique/Zimbabwe, Tanzania and Zambia, respectively. Here, we describe a novel arenavirus in M. natalensis from Gairo district of central Tanzania, for which we propose the name Gairo virus. Surprisingly, the virus is not closely related with Morogoro virus that infects M. natalensis only 90 km south of Gairo, but clusters phylogenetically with Mobala-like viruses that infect non-M. natalensis host species in Central African Republic and Ethiopia. Despite the evolutionary distance, Gairo virus shares basic ecological features with the other M. natalensis-borne viruses Lassa and Morogoro. Our data show that M. natalensis, carrying distantly related viruses even in the same geographical area, is a potent reservoir host for a variety of arenaviruses.
E-info
https://repository.uantwerpen.be/docman/iruaauth/7a7d53/c380bc9972b.pdf
Full text (open access)
https://repository.uantwerpen.be/docman/irua/694f59/9273.pdf
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