Title
Functional changes in the language network in response to increased amyloid <tex>$\beta$</tex> deposition in cognitively intact older adults
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
New York ,
Subject
Human medicine
Source (journal)
Cerebral cortex. - New York
Volume/pages
26(2016) :1 , p. 358-373
ISSN
1047-3211
ISI
000370972500033
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Word finding symptoms are frequent early in the course of Alzheimer's disease and relate principally to functional changes in left posterior temporal cortex. In cognitively intact older adults, we examined whether amyloid load affects the network for language and associative-semantic processing. Fifty-six community-recruited subjects (5274 years), stratified for apolipoprotein E and brain-derived neurotrophic factor genotype, received a neurolinguistic assessment, 18F-flutemetamol positron emission tomography, and a functional MRI of the associative-semantic system. The primary measure of amyloid load was the cerebral-to-cerebellar gray matter standardized uptake value ratio in a composite cortical volume of interest (SUVRcomp). The primary outcome analysis consisted of a whole-brain voxelwise linear regression between SUVRcomp and fMRI response during associative-semantic versus visuoperceptual processing. Higher activity in one region, the posterior left middle temporal gyrus, correlated positively with increased amyloid load. The correlation remained significant when only the word conditions were contrasted but not for pictures. According to a stepwise linear regression analysis, offline naming reaction times correlated positively with SUVRcomp. A binary classification into amyloid-positive and amyloid-negative cases confirmed our findings. The left posterior temporal activity increase may reflect higher demands for semantic control in the presence of a higher amyloid burden.
E-info
https://repository.uantwerpen.be/docman/iruaauth/f48ad5/ab520d9d2c1.pdf
Full text (open access)
https://repository.uantwerpen.be/docman/irua/fa71d0/122626_2017_02_01.pdf
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