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Title
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Diagnostic accuracy of cerebrospinal fluid amyloid- isoforms for early and differential dementia diagnosis
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Author
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Abstract
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| Background: Overlapping cerebrospinal fluid biomarkers (CSF) levels between Alzheimer's disease (AD) and non-AD patients decrease differential diagnostic accuracy of the AD core cerebrospinal fluid (CSF) biomarkers. Amyloid-β (Aβ) isoforms might improve the AD versus non-AD differential diagnosis. Objective: To determine the added diagnostic value of Aβ isoforms, Aβ1-37, Aβ1-38, and Aβ1-40, as compared to the AD CSF biomarkers Aβ1-42, T-tau, and P-tau181P. Methods: CSF from patients with dementia due to AD (n = 50), non-AD dementias (n = 50), mild cognitive impairment due to AD (n = 50) and non-demented controls (n = 50) was analyzed with a prototype multiplex assay using MSD detection technology. The non-AD group consisted of frontotemporal dementia (FTD; n = 17), dementia with Lewy bodies (DLB; n = 17), and vascular dementia (n = 16). Results: Aβ1-37 and Aβ1-38 increased accuracy to differentiate AD from FTD or DLB. Aβ1-37, Aβ1-38, and Aβ1-40 levels correlated with Mini-Mental State Examination scores and disease duration in dementia due to AD. The Aβ1-42/Aβ1-40 ratio improved diagnostic performance of Aβ1-42 in most differential diagnostic situations. Aβ1-42 levels were lower in APOE ε4 carriers compared to non-carriers. Conclusions: Aβ isoforms help to differentiate AD from FTD and DLB. Aβ isoforms increase diagnostic performance of Aβ1-42. In contrast to Aβ1-42, Aβ isoforms seem to be correlated with disease severity in AD. Adding the Aβ isoforms to the current biomarker panel could enhance diagnostic accuracy. |
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Language
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English
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Source (journal)
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Journal of Alzheimer's disease. - -
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Publication
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2015
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ISSN
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1387-2877
1875-8908
[Electronic]
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DOI
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10.3233/JAD-141986
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Volume/pages
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45
:3
(2015)
, p. 813-822
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ISI
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000351608700012
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Pubmed ID
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25633670
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Full text (Publisher's DOI)
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Full text (open access)
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