Publication
Title
Diagnostic accuracy of cerebrospinal fluid amyloid- isoforms for early and differential dementia diagnosis
Author
Abstract
Background: Overlapping cerebrospinal fluid biomarkers (CSF) levels between Alzheimer's disease (AD) and non-AD patients decrease differential diagnostic accuracy of the AD core cerebrospinal fluid (CSF) biomarkers. Amyloid-β (Aβ) isoforms might improve the AD versus non-AD differential diagnosis. Objective: To determine the added diagnostic value of Aβ isoforms, Aβ1-37, Aβ1-38, and Aβ1-40, as compared to the AD CSF biomarkers Aβ1-42, T-tau, and P-tau181P. Methods: CSF from patients with dementia due to AD (n = 50), non-AD dementias (n = 50), mild cognitive impairment due to AD (n = 50) and non-demented controls (n = 50) was analyzed with a prototype multiplex assay using MSD detection technology. The non-AD group consisted of frontotemporal dementia (FTD; n = 17), dementia with Lewy bodies (DLB; n = 17), and vascular dementia (n = 16). Results: Aβ1-37 and Aβ1-38 increased accuracy to differentiate AD from FTD or DLB. Aβ1-37, Aβ1-38, and Aβ1-40 levels correlated with Mini-Mental State Examination scores and disease duration in dementia due to AD. The Aβ1-42/Aβ1-40 ratio improved diagnostic performance of Aβ1-42 in most differential diagnostic situations. Aβ1-42 levels were lower in APOE ε4 carriers compared to non-carriers. Conclusions: Aβ isoforms help to differentiate AD from FTD and DLB. Aβ isoforms increase diagnostic performance of Aβ1-42. In contrast to Aβ1-42, Aβ isoforms seem to be correlated with disease severity in AD. Adding the Aβ isoforms to the current biomarker panel could enhance diagnostic accuracy.
Language
English
Source (journal)
Journal of Alzheimer's disease
Publication
2015
ISSN
1387-2877
Volume/pages
45:3(2015), p. 813-822
ISI
000351608700012
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 02.02.2015
Last edited 18.07.2017
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