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Title
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Overdiagnosing vascular dementia using structural brain imaging for dementia work-up
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Author
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Abstract
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| Hypothesizing that non-significant cerebrovascular lesions on structural brain imaging lead to overdiagnosis of a vascular etiology of dementia as compared to autopsy-confirmed diagnosis, we set up at study including 71 patients with autopsy-confirmed diagnoses. Forty-two patients in the population (59%) appeared to have definite Alzheimer's disease (AD), whereas 29 (41%) had a non-AD dementia form. The panel clinically diagnosed possible or probable vascular dementia (VaD) in 27 (38%) patients, whereas only five (19%) patients (p = 0.017) had an autopsy-confirmed diagnosis of VaD. Patients with vascular lesions on structural brain imaging were often misdiagnosed as possible or probable VaD as compared to autopsy-confirmed diagnosis. |
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Language
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English
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Source (journal)
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Journal of Alzheimer's disease. - -
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Publication
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2015
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ISSN
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1387-2877
1875-8908
[Electronic]
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DOI
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10.3233/JAD-142103
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Volume/pages
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45
:4
(2015)
, p. 1039-1043
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ISI
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000352819200004
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Pubmed ID
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25633672
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Full text (Publisher's DOI)
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Full text (open access)
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