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Title
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Rat brain normalization templates for robust regional analysis of []ABP688 positron emission tomography/computed tomography
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Author
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Abstract
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| A methodology to generate rat brain templates for spatial normalization of positron emission tomographic (PET)/computed tomographic (CT) images is described and applied to generate three different templates for imaging of [11C]ABP688, a PET ligand binding to the metabotropic glutamate 5 receptor. The templates are based on functional (PET), structural (CT), and combined PET and CT information, respectively. The templates are created from a testretest study under normal conditions and are used to assess the different templates by using them in the analysis pipeline of a testretest and a blocking experiment. The resulting average nondisplaceable binding potentials (BPND) show significant (analysis of variance, p , .05) and substantial (up to 23%) differences between the different approaches in several brain regions. The highest BPND values in receptor-rich regions are obtained using the PET-based approach. This approach also had the smallest variability in all tested regions (standard error of measurement of 9% versus 14% [PET/CT] and 20% [CT]). All approaches showed similar relative changes in BPND values with increased blocking. Taken together, these results suggest that the use of the tracer-specific PET-based template outperforms the other approaches with the performance of the combined PET/CT template between those of the PET and the tracer-independent CT template. |
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Language
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English
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Source (journal)
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Molecular imaging
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Publication
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2015
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ISSN
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1535-3508
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DOI
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10.2310/7290.2014.00037
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Volume/pages
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14
(2015)
, 14 p.
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ISI
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000351643500009
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Full text (Publisher's DOI)
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Full text (open access)
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