Title
Cloning and tissue distribution of the chicken type 2 corticotropin-releasing hormone receptor Cloning and tissue distribution of the chicken type 2 corticotropin-releasing hormone receptor
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New York ,
Subject
Biology
Source (journal)
General and comparative endocrinology. - New York
Volume/pages
138(2004) :1 , p. 89-95
ISSN
0016-6480
ISI
000222816500011
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
We report the cloning of the complete coding sequence of the putative chicken type 2 corticotropin-releasing hormone receptor (CRH-R2) by rapid amplification of cDNA ends (RACE). The chicken CRH-R2 is a 412-amino acid 7-transmembrane G protein-coupled receptor, showing 87% identity to the Xenopus laevis and Oncorhynchus keta CRH-R2s, and 7880% to mammalian CRH-R2s. The distribution of CRH-R2 mRNA was studied by RT-PCR analysis and compared to CRH-R1 distribution. Both CRH-R1 and CRH-R2 mRNA are expressed in the main chicken brain parts. In peripheral organs, CRH-R1 mRNA shows a more restricted distribution, whereas CRH-R2 mRNA is expressed in every tissue investigated, indicating that a number of actions of CRH and/or CRH-like peptides remain to be discovered in the chicken as well as in other vertebrates.
E-info
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