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Title
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Cloning and tissue distribution of the chicken type 2 corticotropin-releasing hormone receptor
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Author
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Abstract
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| We report the cloning of the complete coding sequence of the putative chicken type 2 corticotropin-releasing hormone receptor (CRH-R2) by rapid amplification of cDNA ends (RACE). The chicken CRH-R2 is a 412-amino acid 7-transmembrane G protein-coupled receptor, showing 87% identity to the Xenopus laevis and Oncorhynchus keta CRH-R2s, and 7880% to mammalian CRH-R2s. The distribution of CRH-R2 mRNA was studied by RT-PCR analysis and compared to CRH-R1 distribution. Both CRH-R1 and CRH-R2 mRNA are expressed in the main chicken brain parts. In peripheral organs, CRH-R1 mRNA shows a more restricted distribution, whereas CRH-R2 mRNA is expressed in every tissue investigated, indicating that a number of actions of CRH and/or CRH-like peptides remain to be discovered in the chicken as well as in other vertebrates. |
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Language
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English
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Source (journal)
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General and comparative endocrinology. - New York
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Publication
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New York
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2004
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ISSN
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0016-6480
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DOI
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10.1016/J.YGCEN.2004.05.006
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Volume/pages
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138
:1
(2004)
, p. 89-95
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ISI
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000222816500011
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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