Title
Postgenomic characterization of G-protein-coupled receptors Postgenomic characterization of G-protein-coupled receptors
Author
Faculty/Department
Faculty of Sciences. Chemistry
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Subject
Biology
Source (journal)
Pharmacogenomics
Volume/pages
5(2004) :6 , p. 657-672
ISSN
1462-2416
1744-8042
ISI
000224611400011
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
G-protein-coupled receptors (GPCRs) constitute one of the largest families of membrane-spanning proteins. Their importance in drug development has been proven over and over again. Therefore, they remain one of the most significant groups of molecules to be characterized. In the postgenomic era, the methods used for the characterization of GPCRs have dramatically changed: the predicted orphan receptors are now often used to ascertain the ligands (reverse pharmacology), whereas, in the past, the bioactive ligand was used to identify the receptor (classic approach). In this review, we will give an overview of the recent postgenomic functional assays that are frequently used to link the orphan GPCR of both vertebrate and invertebrate organisms with their ligands.
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