Title
PDF receptor signaling in **Drosophila** contributes to both circadian and geotactic behaviors PDF receptor signaling in **Drosophila** contributes to both circadian and geotactic behaviors
Author
Faculty/Department
Faculty of Sciences. Chemistry
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Cambridge, Mass. ,
Subject
Biology
Source (journal)
Neuron. - Cambridge, Mass.
Volume/pages
48(2005) :2 , p. 213-219
ISSN
0896-6273
ISI
000232838700011
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
The neuropeptide Pigment-Dispersing Factor (PDF) is a principle transmitter regulating circadian locomotor rhythms in Drosophila. We have identified a Class II (secretin-related) G protein-coupled receptor (GPCR) that is specifically responsive to PDF and also to calcitonin-like peptides and to PACAP. In response to PDF, the PDF receptor (PDFR) elevates cAMP levels when expressed in HEK293 cells. As predicted by in vivo studies, cotransfection of Neurofibromatosis Factor 1 significantly improves coupling of PDFR to adenylate cyclase. pdfr mutant flies display increased circadian arrhythmicity, and also display altered geotaxis that is epistatic to that of pdf mutants. PDFR immunosignals are expressed by diverse neurons, but only by a small subset of circadian pacemakers. These data establish the first synapse within the Drosophila circadian neural circuit and underscore the importance of Class II peptide GPCR signaling in circadian neural systems.
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